CASA Research


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Garry Corthals - Biomolecular Systems Analytics

Garry is the current Chair in Supramolecular Separations at the University of Amsterdam's Faculty of Science. Garry’s group aims at solving questions in life sciences from a molecular perspective with an emphasis on proteome technology.
The work in our group focuses on the development of a variety of technologies involving mass spectrometry (MS), and the application of this MS to a wide-range of biomedical applications.

In addition to the Life Sciences research they have initiated two new programs with other groups in Amsterdam in (i) forensics at the Co van Ledden Hulsebosch Center, and (ii) with conservation science in the 'Science for Art' project, involving research with the colleagues at the Netherlands Institute for Conservation, Art and Science (NICAS).

The four main areas of interest are:

  • mass spectrometric tools and allied technologies aimed at sensitive and quantitative analysis of proteins and their PTMs
  • separation sciences that can efficiently resolve complex molecular mixtures so their analysis is within the capacity of our analytical technology
  • apply new chemistries (in methods and molecules) to biomedical applications to reveal molecular functional information of protein networks and protein complexes
  • computational methods to assist in the efficient validation and understanding of proteome-scale analysis of biomolecular systems

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Govert Somsen - Biomolecular Analysis/Analytical Chemistry

Govert is Chair of the Biomolecular Analysis/Analytical Chemistry group at the Free University of Amsterdam. The mission of the group is to design, understand and apply novel and improved analytics in order to gain new and better insights into biomolecular and drug characteristics, and biological and chemical processes.
Research is directed towards methodological innovation and increased information content to solve life-science queries and the focus is on advanced sample-preparation and separation techniques in combination with state-of-the-art MS, optical spectroscopy and bio-activity detection. Hyphenation, integration, miniaturization and automation, are important aspects to face demands on selectivity, sensitivity, speed and data handling.

Currently the group is focused on the development of novel analytical methodologies for the characterization, discovery and trace analysis of biologically active compounds.

The three main areas of interest are:

  • Compositional and conformational characterization of intact biomacromolecules using highly selective separation in combination with high-resolution (tandem) mass spectrometry and optical spectroscopy
  • Development and application of high-resolution screening technologies enabling the simultaneous probing of bio-activity and identity of components in complex samples
  • Targeted and untargeted metabolite analysis in biofluids with particular attention for metabolite chirality