This award is given each year to the individual who is an outstanding scientist in the field of chromatography. The awardee is selected on the basis of his or her contributions to the fundamental understanding of the chromatographic process.
Upcoming events where we will be speaking and presenting our research.
MSBM XIII Summer School on Mass Spectrometry in Biotechnology & Medicine
7 - 13 July 2019, Dubrovnik, Croatia.
The 13th Mass Spectrometry in Biotechnology and Medicine (MSBM) will be held again in Dubrovnik, Croatia at the Centre for Advanced Academic Studies.
Friday, 1 March 2019
1071 ZC Amsterdam
Room B (RCE)
Chair: Alina Astefanei
|13:30||Peter Schoenmakers (UvA)||CASA update|
|13:40||Enrico Cappellini (University of Copenhagen; Natural History Museum of Denmark)||Palaeoproteomic analysis of cultural heritage|
|14:10||Inez van der Werf (RCE, Amsterdam)||MALDI-MS procedures for paint binder analysis|
|14:30||Klaas Jan van den Berg (RCE; UvA)||Materials research on modern paintings performed at the Cultural Heritage Agency|
Chair: Maarten van Bommel
|15:20||Maarten van Bommel (UvA)||Introducing Too COLD project|
|15:30||Mimi den Uijl (UvA)||TooCOLD – Designing an offline degradation system|
|15:45||Iris Groeneveld (VU)||The design of a flow-cell to initiate and study the chemistry of light induced degradation|
|16:00||Sanne Berbers (RCE)||tba|
RCE: Rijksdienst voor het Cultureel Erfgoed / Cultural Heritage Agency of the Netherlands
30 January - 1 February 2019, Amsterdam, The Netherlands
Ninth International Symposium on Separation and Characterization of Natural and Synthetic Macromolecules.
SCM-9 bring together scientists, who share an interest in the separation and characterization of “large” molecules. It offers a platform for scientists to interact, to discuss subjects of mutual interest, and to discover new synergies.
Analytics in Metabolomics
Friday, 2 November 2019
Location: VU university (O|2 Building, Room 00E63 (Popup)
Time: 14:00 -18:00
Analytics in Metabolomics: Is it the analytics that drives metabolomics, or metabolomics that drives the analytics?
Download the programme
ISC 2018, 32nd International Symposium on Chromatography
23 - 27 September 2018, Cannes Mandelieu, France
The International Symposium on Chromatography (ISC) represents a traditional congress series of major European Chemical Societies. It is one of the premier meetings for discussion of all modes of chromatography and separation sciences with a broad coverage of techniques and applications.
Celebrating the Success of the MSc Analytical Sciences
Friday, 31 August 2018
Alumni programme (MSc Analytical Sciences)
Lab visit – Posters – Lunch
Location: Science Park 904, 1098 XH Amsterdam, C and D-building
Time: from 12:00
Location: Science Park 904, room C1.110
• 14:00 Introduction by Peter Schoenmakers
• 14:15 Rob Edam (Shell)
• 14:30 Ewoud van Tricht (Crucell/J&J)
• 14:45 Maria Marioli (Teva Pharma)
• 15:00 Bob Pirok (MANIAC, Uva)
• 15:15 Noor Abdulhussain (STAMP, UvA)
• 15:30 Extroduction by Henk Lingeman (VU, MSc Analytical Sciences) and Wim Kok
Location: De Oerknal (USC) 16:15
HPLC 2018, 47th Symposium on High Performance Liquid Phase Separations and Related Techniques
29 July - 2 August 2018, Washington, DC, USA
The HPLC 2018 conference has grown to become the largest and most visible international conference series dedicated to all aspects of liquid-phase separation science and analysis, including mass spectrometry, chromatography, and electrophoresis.
MSBM XII Summer School on Mass Spectrometry in Biotechnology & Medicine
8 - 14 July 2018, Dubrovnik, Croatia.
The 12th Mass Spectrometry in Biotechnology and Medicine (MSBM) will be held again in Dubrovnik, Croatia at the Centre for Advanced Academic Studies.
42nd International Symposium on Capillary Chromatography (ISCC) and 15th GCxGC Symposium
May 13 - 18, 2018 Congress Centre, Riva del Garda, Italy.
The 42nd International Symposium on Capillary Chromatography (ISCC) is the premier meeting for pressure and electrodriven microcolumn separations and related techniques.
The program will include plenary lectures, keynote lectures by young scientists, prominently featured poster presentations, an instrument exhibition displaying the latest instrumental innovations, and a highly attractive social program offering opportunities to meet with world-renown scientists.
The 15th GCxGC Symposium will be organized jointly with the ISCC meeting to allow scientists to attend both meetings.
Join us for an exciting programme focused on the cornerstones of separation science: data analysis, separation science theory and implementation.
Monday, 7 May 2018
13:30 - 17:00
Amsterdam Science Park Congress Centre
Sciencepark 105, 1098 XG Amsterdam
Wednesday, 14 March 2018
Science Park 904
Room SP C1.112
|15:00||Alan Garcia Cicourel, HIMS||Mineral Oil Analysis in Consumer Products|
|15:20||Arian van Asten, HIMS, NFI||The Potential of Comprehensive Gas Chromatography in Forensic Fire Investigations|
|16:00||Prof. Jef Focant, Organic and Biological Analytical Chemistry Group, Universite de Liege||Contribution of GCxGC-(HR)TOFMS to Forensics and Medical Applications|
|16:50||Jeroen Kool, AIMMS||Capillary Separations Hyphenated to Bioassays: GC-nanofractionation and NanoLC-picofractionation|
15th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology
24 - 26 January 2018, Cardiff, UK
HTC will been held in the UK at Cardiff City Hall and will be the premier analytical meeting in the UK for 2018, attracting national and internationally renowned scientist. The Meeting is organised by the Royal Society of Chemistry Separation Science Group with the Royal Flemish Chemical Society.
CASA Minore in Spiaggia event
Monday, 4 September 2017, 14:30-20:30
Beach Club Tijn Akersloot
Boulevard Paulus Loot 1B, Zandvoort
Summer School on Mass Spectrometry in Biotechnology & Medicine
2 - 8 July 2017, Dubrovnik, Croatia
3rd International Mass Spectrometry School (IMSS), organised by the Netherlands MS society (NVMS) on behalf of the International Mass Spectrometry Foundation (IMSF), will be jointly held with the 11th Mass Spectrometry in Biotechnology & Medicine Summer School.
HPLC 2017 Prague
18 - 22 June 2017, Prague, Czech Republic
45th International Symposium on High Performance Liquid Phase Separations and Related Techniques.
The conference program covers all aspects of fundamental and experimental approaches, novel instrumentation, column technologies and cutting-edge applications & instrumentation. The important feature is the coupling with mass spectrometry therefore one program track is devoted to hyphenated techniques only.
Amsterdam Mass Spectrometry (AMS-MS) network
6 June 2017, 16:00-19:30
Academic Medical Centre Amsterdam
The AMS-MS network has the objective to bring together all the mass spectrometry researchers in Amsterdam, ranging from BSc/MSc students, PhDs, post-docs, technicians, scientific staff, and PIs.
We will furthermore discuss and elaborate on the plans regarding MS related courses, collaborations and facilities that have been discussed at the previous meeting.
Inaugural event Maarten van Bommel
Thursday 11 May 2017, 16:00.
Aula der Universiteit, Singel 411, Amsterdam
dr. ing. M. R. van Bommel (NICAS) appointed as Hoogleraar Natuurwetenschappelijke aspecten van conservering en restauratie van roerend cultureel erfgoed.
His inaugural lecture (in Dutch) is titled: Conservation science in perspectief: De rol van de natuurwetenschappen in conservering en restauratie van cultureel erfgoed.
CASA Chromametrics / Microseparations Event
Thursday, 30 March 2017, 13:00-16:45, followed by drinks.
Vrije Universiteit, O|2 building, de Boelelaan 1100, room 01W08.
Invited speaker: Mike Ramsey (University of North Carolina).
MSB 2017 Noordwijkerhout
26 - 29 March 2017, Noordwijkerhout, The Netherlands
33rd International Symposium on Microscale Separations and Bioanalysis
MSB 2017 embodies an interactive forum for the discussion of cutting-edge research on the frontiers of separation science, spanning fundamental theory/method/technology development to high-impact applications relevant to health, medicine, food and the environment
1 - 3 February 2017, Amsterdam, The Netherlands
Eighth International Symposium on Separation and Characterization of Natural and Synthetic Macromolecules
Friday 13 January 2017, 13:00
The event will take place between 13:00 and 16:00, followed by drinks.
The lectures will take place at the OZW gebouw, de Boelelaan 1109, room 1A-01.
American Chemical Society (ACS) visits UvA campus
ACS on Campus, the American Chemical Society’s premier outreach program, is coming to University of Amsterdam on Wednesday, 16 November.
Engaging talks on the latest innovations in science, behind-the-scenes of the scholarly publishing process, and developing your career in the sciences.
CASA GOES PICOLO
Monday 17 October 2016, 14:30-17:00
VU-campus, O|2 building, room 01W08, de Boelelaan 1108, Amsterdam (map)
Chair Govert Somsen
14:30 – Opening Govert Somsen - CASA update
14:40 – Bert Wouters - Design and application of a microfluidic immobilized-enzyme reactor for rapid digestion of various natural macromolecules (UvA)
15:00 – Elena Dominguez Vega - Microfluidic flow cell for on-line CE-SPR (VU)
15:20 – Alina Astefanei - Title to be announced (UvA)
15:40 – Coffee Break
Chair Peter Schoenmakers
16:00 – Jeroen Kool - Microfluidic and nanofractionation analytics for venom profiling (VU)
16:20 – Rosanne Guijt - 3D printing for microfluidics (University of Tasmania, Hobart, Australia)
17:00 – Drinks
Special “Last Minute” Invitation
Prof Almirall is an experienced forensic chemist with an impressive career in both law enforcement and forensic science.
On request of the CLHC he will give two presentations during his stay in the Netherlands in two special forensic colloquiums.
On Monday he will present his latest research on printing ink evidence at Amsterdam Science Park and on Tuesday recent work on chemical identification strategies of new psychoactive substances will be discussed at the NFI.
All with a forensic chemistry interest are invited to attend these presentations.
Monday 20 June, Amsterdam
• 14:00-15:00 Colloquium at UvA Science Park
Comparison and Characterization of Printing Ink Evidence
Room C1.112, Building 904
Tuesday 21 June, The Hague
• 14:30-15:30 Colloquium at NFI
Growth of NPS in the USA and analytical strategies for chemical identification
Co van Ledden Hulsebosch Auditorium
Netherlands Forensic Institute
Laan van Ypenburg 6
2497 GB The Hague
X Summer School on Mass Spectrometry in Biotechnology & Medicine
3 - 9 July 2016, Dubrovnik, Croatia
CASA Mass Spectacular Day
Wednesday 20 April 2016, 13:00-16:00
UvA Science Park 904, Room C1.110, Amsterdam
Sponsors of the event are Sciex (www.sciex.com).
UvA Faculty of Science College Tour: Green Forensics - CSI in horticulture
Lecture announcement 6 April 2016 20.00 - 21.30 at Spui 25 Amsterdam
Crime in horticulture, does not sound like a very common problem. And yet, fraud with flowers and plants is everyday's business. It is estimated that 12.5% of the flowers and plants are illegally propagated. How do you track these illegal practices? A double lecture of UvA researcher Eva de Rijke and molecular biologist from Naktuinbouw Hedwich Teunissen.
CASA Master Event
Friday 18 March 2016, 14:00-18:00
VU, De Boelelaan 1085, Room F123, W&N-building, Amsterdam
Our students are in the spotlight at the CASA master event.
The event is intended for
- MSc and BSc students that are conducting analytical-chemistry research projects in Amsterdam
- Students that may conduct such a project in the future
- Members of CASA groups
During the event
- MSc students will present examples of successful internships
- Useful information for students will be presented
- Students can find projects (and staff can find students)
CASA Campagna Event
12 Februari 2016
Turingzaal at the CWI conference centre, Science Park 125, Amsterdam
Human Proteome Organisation 2015 congress
26 - 30 September 2015, Vancouver, Canada
5th Nordic Proteomics Symposium,
the 14th Swedish Proteomics Society Symposium
23 - 25 August 2015, Malmö, Sweden
Mini Symposium Innovative Analytical Approaches in ADME
Analytical research in Absorption, Distribution, Metabolism and Excretion (ARIADME) is a Marie Skłodowska-Curie initial training network, which aims to build individual training paths for a new generation of young scientist in the field of ADME. A group of 13 PhD researches, who were enrolled in the consortium consisting of 4 academic and 2 industrial partners are working together on improving and expanding current ADME profiling analytics and methods by:
1) innovative in vitro and in vivo ADME tools
2) novel analytical methodologies and
3) new approaches for ADME data handling and computational modelling.
The mini-symposium is a part of the workshop, which is opened to the general public. This year (on Thursday 27 August 2015, at VU University) the theme of the workshop and also the title of the mini-Symposium is “Innovative analytical approaches in ADME”. During the mini-symposium, experts in the field will present innovations in analytical techniques for ADME profiling, progress in the research and future perspectives. The participant will learn about new analytical methods used for metabolite profiling and identification, analytics for biopharmaceuticals, the importance of membrane transporters in the pharmacokinetics and toxicity of drugs, and also about new, more definitive tests for heroin abuse. The mini-symposium will end with a lecture of Jeremy Nicholson entitled: “Systems Medicine and Molecular Phenomics”.
IX Summer School on Mass Spectrometry in Biotechnology & Medicine
5 - 11 Jul 2015, Dubrovnik, Croatia
EuPA 2015 meeting
23 - 28 June 2015, Milan, Italy
Peter Schoenmakers (HIMS/Analytical Chemistry) received the Chromatography Forum of the Delaware Valley Dal Nogare Award during the Pittcon Conference and Expo 2019.
Veni laureate Dr Andrea Gargano has been appointed as tenure track researcher within the Analytical Chemistry theme at the Van 't Hoff Institute for Molecular Sciences (HIMS). His research focuses on the use of advanced separation science technology and high-resolution mass spectrometry for the characterization of natural and synthetic polymers.
In particular, Gargano's research is centered on the coupling of liquid chromatography and mass spectrometry to study the micro-heterogeneity (e.g., the chemical composition) of intact polymers, natural as well as synthetic. Examples of natural polymers are enzymes used in biotechnology and proteins, acting players of life whose function is regulated through chemical modifications (e.g., phosphorylation). Synthetic polymers are for instance high-performance polymers used for advanced coatings in material science.
Keep it intact
These two very diverse class of molecules have in common that they are of high molecular weight and have multiple distributions (e.g., with respect to molecular weight, conformation, etc.). Due to technological limitations, their properties are studied looking at fragments or average properties. Yet, much (important) information regarding their distributions cannot be characterized by the current approaches and is awaiting new technologies to be studied.
Prior to his tenure track appointment at HIMS, Andrea Gargano has worked on his project 'Intact Protein Analysis' for which he received an NWO Veni grant in 2016. In this, he has explored innovative analytical methods to push forward the technology to characterize protein distribution in proteoforms. He performs experiments both at the Bio-Analytical Chemistry group of the Vrije Universiteit and the Analytical Chemistry group at HIMS (united as CASA, the Center for Analytical Science Amsterdam). He collaborates with renowned research institutes such as the Pacific Northwest National Laboratory (WA, USA), Northwestern University (IL, USA), Leiden University Medical Center (Leiden, NL) and DSM Biotechnology Center (Delft, NL).
Andrea Gargano was awarded the Ernst-Bayer Award in 2014 and the Csaba Horváth Young-Scientist Award in 2015. In October 2018 the Analytical Scientist magazine listed him among the 'Fab Forty' of gifted young scientists 'making waves in analytical science.'
The Analytical Scientist Power List 2018
The Fab Forty, the Top 40 Under 40 Power List 2018 consists of gifted young scientists making waves in analytical science. Andrea Gargano (VU Amsterdam) was one of the rising stars of the field, nominated by The Analytical Scientist readers and shortlisted by an independent judging panel.Website: https://theanalyticalscientist.com/power-list/2018/
Iro Ventouri, who is preparing a joint PhD in the VU/UvA project HOSAna, won a poster prize at the 32nd International Symposium on Chromatography (ISC 2018) in Cannes-Mandelieu, France (September 23 – 27, 2018) for her poster entitled "Native asymmetrical flow field-flow fractionation and size-exclusion chromatography for studying aggregation of beta-D-galactosidase". Iro is collaborating with HOSAna partners, in particular with Postnova and the DSM Biotechnology Centre (Dr. Erwin Kaal).Iro excelled because of the quality of her work and because of the energy and enthusiasm she put in her presentation.
Congratulations to Iro for a brilliant effort!
Peter Schoenmakers (HIMS/Analytical Chemistry) will be awarded with the 2018 Fritz-Pregl Medal of the Austrian Society of Analytical Chemistry (ASAC) during the 32nd International Symposium on Chromatography ISC 2018.
This highest award of the ASAC will be given to scientists who have contributed outstanding developments in Analytical Sciences.
Throughout his career, Peter Schoenmakers has devoted his scientific enthusiasm towards separation sciences, and in particular, towards liquid chromatography theory and practice. His contributions and innovations advanced the field significantly and had high impact on the today’s standing of the large portfolio on separation technologies, essentially applied in all fields of chemistry, life science, environmental science, and materials science, among others.Read more
At the International Symposium on Capillary Chromatography in Riva del Garda (Italy), Bob Pirok won the Journal of Chromatography A Young Scientist Award for his MANIACal efforts on coupling incompatible systems and on efficient method development for one- and two-dimensional LC (the PIOTR program).
After the Young-Scientist award in Beijing in 2015, the SCM Young-Scientist Award Lecture in 2017 and – most prestigious of all – the Csaba Horváth Young-Scientist Award earned in Prague also in 2017, this is Bob’s fourth (!) international award. Bob is definitely an award maniac!
The COAST Community Challenge was organized during FAST 2018 (May 29-30 in Veldhoven, The Netherlands). Experts from private companies and institutes challenged some 80 young scientists with difficult problems from real (industrial) practice. The latter responded with many good suggestions and the best of these will get support to perform a feasibility study.
A very strong team that identified themselves as “The Sweaty Students” – an unspecific characterization, because non-sweating students were found nowhere in blazing hot Veldhoven during the meeting – won the challenge, addressing the “How to Hyphenate?” challenge from Maurice Janssen (MassSpecpecD). Amsterdam students dominated the team. Fleur van Beek deserves special mention, because she led a different team to victory in a different challenge during FAST 2017 (and she won a big Poster Award at CHAINS 2016). You may have guessed – Fleur is a MANIAC.
Improving phosphoproteome identification through simulation of phosphopeptide tandem mass spectra.
Analytical chemists including Garry Corthals from the University of Amsterdam's Van 't Hoff for Molecular Sciences (the Netherlands) and Veronika Suni of the University of Turku's Center for Biotechnology (Finland) present SimPhospho, a fast and user-friendly open source tool for accurate simulation of phosphopeptide tandem mass spectra.
With SimPhospho, simulated phosphopeptide spectral libraries are used to validate and supplement database search results. It thus can improve reliable phosphoproteome identification and reporting. The program can be easily used together with the Trans-Proteomic Pipeline and it can be integrated in a phosphoproteomics data analysis workflow.
SimPhospho is open source and it is available for Windows, Linux and Mac operating systems.Read more
The third ALE seasonal school took place at the University of Edinburgh, Scotland, from April 18 to 20, 2018. The course was excellently organized by Prof. Simone Dimartino and his PhD student Ursula Simon. ALE is a collaboration between the universities of Amsterdam, Leuven (B) and Edinburgh in the context of the League of European Research Universities (LERU).
From Amsterdam Suhas Nawada and Dorina Adamopoulou aided in the organization. They also contributed significantly to the scientific content of the course. Other notable contributors from Amsterdam included Niall Macdonald, Sinéad Currivan, Noor Abdulhussain, Marta Passamonti and Leon Niezen.
The course attracted a number of delegates from other universities and companies and featured presentations from the KIT (Karlsruhe, D), UCL (London, UK) and VUB (Brussels, B).
The last ALE course will centre on “Chromatography and Hyphenation” and will take place in Nijmegen (NL), from August 20 to 24, 2018.
The COAST Education Day on April 10 at the Hogeschool Utrecht was the scene of the final of the COAST-Student-Innovation-Award Competition.
Mimi den Uijl was the very convincing winner.
She presented a pitch on her MSc project, conducted at Shell Amsterdam under the supervision of Wim Genuit. The title of her project was "Extending the scope of gas chromatography - mass spectrometry by means of supersonic molecular beams".
Mimi won an Apple iPad and she has been invited to present a plenary lecture at an international conference (FAST2018, May 29-30, Veldhoven).
Mimi is a student in the Analytical-Chemistry track of the UvA/VU MSc Chemistry program. She also participates in the COAST MSc+ honours program. This summer she will start working towards a joint UvA/VU PhD in the TooCOLD project led by Maarten van Bommel.
"Mimi from Mokum" exemplifies Amsterdam and CASA.
Collaboration of CASA groups with DSM, AkzoNobel and BASF attracts substantial funding
The CASA team of Govert Somsen (VU), Peter Schoenmakers and Ron Peters (UvA) received a grant of in total 1688 kEuro for the project UNMATCHED. The proposal was granted by NWO ENW in the Chemical Industrial Partnership Programme (CHIPP) from the Innovation Fund for Chemistry. The CASA groups team up with researchers from the companies DSM, AkzoNobel and BASF to develop new analytical techniques for advanced polymers.
UNMATCHED: UNderstanding MATerials by CHaracterizing Essential Distributions
Many modern (bio)materials are composed of polymers. Today, increasingly smarter chemical strategies are developed to make more and more complex polymer molecules, which comprise multiple structural distributions. Current analytical methods are not able resolve this molecular diversity. As a consequence, polymer structures cannot be correlated adequately to functional properties. The UNMATCHED project aims to develop innovative highly-selective analytical methods for enhanced separation and detection of complex (bio)polymers. This will aid in better understanding of polymer properties and function, and ultimately in the production of more sophisticated polymer materials.
The total budget for UNMATCHED is 1.7 MEuro, of which 750 kEuro is funded by the industrial partners. A coherent team of four PhD students and two postdocs will work in both VU and UvA laboratories. They will also be seconded for substantial periods to the company labs, with a focus on implementing newly developed UNMATCHED systems in industry.Read more (in Dutch)
Arian van Asten (University of Amsterdam/Netherlands Forensic Institute) and Joris Dik (Delft University of Technology) published an article titled: “Large area imaging of forensic evidence with MA-XRF” in Scientific Reports (an online, open access journal from the publishers of Nature). They showed the successful application of macro X-ray Fluorescence (MA-XRF) in the field of forensic science.
First author of the publication is Kirsten Langstraat, student of the Forensic Science Master program at the UvA. Langstraat conducted most of the practical work during an internship with the gunshot residue team at NFI and in collaboration with the NFI teams for crime scene investigation and biological traces. The study introduces the use of Macro X-ray Fluorescence (MA-XRF) imaging for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. Until now XRF scanning has been applied only for moderate surface areas with 2D micro XRF (2D μ-XRF). Mobile XRF scanners as used at the museum allow for the elemental mapping of much larger surfaces, such as encountered at crime scenes. MA-XRF was sensitive and selective enough to detect human biological traces like blood, semen, saliva, sweat and urine on fabric on the basis of Fe, Zn, K, Cl and Ca elemental signatures. Furthermore, the technique could be employed for the chemical imaging and classification of gunshot residues (GSR) and even be used to provide information on the shooting order of different ammunition types.read the full paper
The 2017 edition of the 'Power List' compiled by the magazine 'the Analytical Scientist' features ten categories. Peter Schoenmakers of the University of Amsterdam's Van 't Hoff Institute for Molecular Sciences (HIMS) is listed in two of these 'Magnificent Tens'. As runner up in the category 'separation scientists' and at third place in the 'leaders' section he continues his strong performance in this bi-annual international listing of academic relevance.
The Analytical Scientist power list is a ranking of the most influential people in the analytical sciences. It is based on a poll among the readers of the magazine and the visitors of its website who nominate scientists, engineers, software developers or business leaders.
In both the 2013 and 2015 editions Schoenmakers, who since the beginning of this year also leads HIMS as scientific director, ranked seven internationally and third in a European perspective. For the current edition the nominations were made in ten specific categories, from the stars of separation science, to 'omics explorers', to the mentors training the next generation. This yielded Peter Schoenmakers a second and a third place in the categories 'separation scientists' and 'leaders', respectively.
Forging the future
Schoenmakers earned his position as runner up in the listing of separation scientists because he is, as one of the nominators put it, "continually forging the future of separation science". An impressive example of this is the current Horizon2020 project 'Separation Technology for A Million Peaks' (STAMP) for which Schoenmakers received an ERC Advanced Grant. In this he explores a three-dimensional approach of liquid chromatography to develop a system to separate up to a million compounds from complex mixtures. The STAMP results will help advance many fields of science, including (molecular) biology, chemistry, health, food, renewable energy and high-tech materials.
Training the next generation
Schoenmakers ranks third among the leaders in the Analytical Sciences since he "is the face of analytical science in Europe and has spent much of his time training the next generation" - again a quote from a nominator. According to Schoenmakers he is highly motivated by working with excellent young people, "who keep asking challenging questions every single day". In his view, one of the challenges lying ahead for the analytical sciences is the education of a next generation of scientists "who are capable of using and understanding the ever more complex techniques and instruments available - and the application domain they work in. Underqualified users are using instruments as black boxes, which creates great risks."
In the much-anticipated and intensively debated 2017 Power List Prof. Gert Desmet from the Vrije Universiteit Brussel (VUB) is the Number 1 separation scientist, followed by Peter Schoenmakers at Number 2. On the unpublished list of luckiest PhD students Dorina Adamopoulou is the undisputed Number 1.
Gert Desmet is also Number 1 on the overall list of Analytical Leaders, where Peter Schoenmakers is Number 3. Prof. Deirdre Cabooter (KU Leuven), who organized the ALE course in Leuven is Number 5 among Pharma Pioneers and Prof Ron Heeren (Maastricht University) is the Number 6 mass spectrometrists. Among the best mentors, Gert Desmet came it at Number 7.
At the HPLC2017 international symposium on high performance liquid-phase separations, held 18-22 June in Prague, PhD researcher Bob Pirok of the Van 't Hoff Institute for Molecular Sciences has won the Csaba Horváth Young Scientist Award, an important prize in the field of Analytical Chemistry.
Pirok outcompeted nine other finalists with his lecture on “Extended multi-dimensional liquid-chromatography systems for comprehensive analysis of complex polymeric nanoparticles”. He presented the use of the novel, comprehensive MANIAC analysis method for the characterization of complex nanoparticles. MANIAC, an acronym for Making Analytically Incompatible Approaches Compatible, was developed at HIMS and CASA, the Centre for Analytical Sciences Amsterdam.
Making the incompatible compatible
MANIAC aims to combine completely different and (seemingly) incompatible separation and characterization systems into a single highly efficient and extensively optimized instrument. It encompasses the integration of various chemical, physical and microbial processes with (multi-dimensional) separation systems. At HPLC2017, Bob Pirok discussed its application in the field of complex polymeric nanoparticles that are, for example, encountered in various coatings (decorative, antireflective and anti-microbial), and drug delivery systems.
Samples containing nanoparticles feature a multitude of parameters, such as particle-size distribution, surface composition, molecular weight and chemical composition. A successful technique for the separation of such complex mixtures is comprehensive two-dimensional liquid chromatography (LC×LC). In LC×LC, a modulator is used to couple the two separation dimensions with different time scales (spanning about two orders of magnitude). The potential of modulators can be further enhanced by allowing fast, controlled chemical reactions to take place.Samples containing nanoparticles feature a multitude of parameters, such as particle-size distribution, surface composition, molecular weight and chemical composition. A successful technique for the separation of such complex mixtures is comprehensive two-dimensional liquid chromatography (LC×LC). In LC×LC, a modulator is used to couple the two separation dimensions with different time scales (spanning about two orders of magnitude). The potential of modulators can be further enhanced by allowing fast, controlled chemical reactions to take place.
Proof of principle
Pirok and co-workers first use hydrodynamic chromatography (HDC) to separate the nanoparticles based on size. Next, the modulator is used to dissolve the nanoparticles, yielding a homogeneous molecular solution for each separated fraction. The molecules are then separated in the second dimension based on their chemical composition, by liquid chromatography (LC) or two-dimensional liquid chromatography (LC×LC), in combination with MS detection when appropriate.
A successful application of the complex interplay of the above-mentioned techniques faces a number of challenges (including solvent and sample incompatibility between the two dimensions). As Pirok demonstrated, these can be overcome by applying the MANIAC approach. He presented proof-of-principle with the analysis of polystyrene and PMMA nanoparticle samples.
VUV Analytics Inc. Announces University of Amsterdam as Academic Grant Recipient
VUV Analytics has announced Dr. Hans-Gerd Janssen as the recipient of their academic grant, which provides Dr. Janssen's laboratory with the use of a VGA-101 Vacuum Ultraviolet (VUV) gas chromatography detector to do novel research in the field of food and cosmetics chemistry."VUV Analytics is excited to award the University of Amsterdam with our detector to help continue the groundbreaking advancements taking place in their labs," said Sean Jameson, vice president of Business Development at VUV Analytics. "Since initially launching the academic grant program, we've received countless top-notch proposals, making the decision process increasingly difficult. Having the opportunity to incorporate VUV spectroscopy into Dr. Janssen's research promises to change how MOSH and MOAH are analyzed going forward."The VGA-101 is the latest advancement in vacuum ultraviolet (VUV) detection featuring an expanded wavelength spectrum and a higher allowable maximum operating temperature. It was designed as a next generation detector that addresses advanced application requirements. The University of Amsterdam will begin their food and cosmetics product characterization work during the summer academic session.
The iCARe team led by PhD Student Fleur van Beek of the Van 't Hoff Institute for Molecular Sciences (HIMS) was awarded the ‘Young Scientist Challenge’ prize during the Forum for Analytical Science and Technology (FAST) held in Veldhoven on May 16-17 2017. The participants were challenged to form groups and create original research plans during a 2-hour brainstorm session. Fleur was chosen to be the Primary Investigator of her group, consisting of Paula Borgonje (University of Groningen), André van den Doel (Radboud University), Alina Astefanei (University of Amsterdam), Milou Santbergen (Wageningen University), Gerjen Tinnevelt (Radboud University), and Nienke van Dongen (Wageningen University). Together they managed to convince both the industrial partners and the jury to invest in their individualized Cellular Activity Reactor project (iCARe). A prize of 5600 euros was awarded to the team so they can employ a student to carry out a feasibility study.
Alina Astefanei (UvA): "Rapid and highly sensitive mass spectrometry by SAWN” and Kristina Still (VU): "Development of a HTC Coagulation Assay for Assessment of Heamotoxic Snake Venoms" were one of the four winners of the Best Poster Awards (offered by Janssen Biologics) at the International Symposium on Microscale Separations and Bioanaysis (MSB) conference (Noordwijkerhout, March 26-29, 2017).
On Thursday 30 March during the CASA Chromametrics / Microseparations event the promotion of Michael Woldegebriel and Andrei Barcaru a day earlier was celebrated with a special cake from COAST.
In the same meeting the four highest ranked contestants presented their CASA logo. Unfortunately, none of the logos was found suited to serve as CASA website logo and template for presentations and posters.
The CASA heads elected Angela Ten Pierick's logo as winner and thus she earns a dinner for two people at Restaurant CASA Nostra.
We are very excited to reveal today the winners of the CASA Logo contest.
But first this is how you voted. As you can see there were 67 voters for 11 logos.Option 4 received the most votes, runner-up is option 9 and the 3rd place is shared by option 5 and 7.
The authors of the 3 (4) most voted logos will be asked to prepare a power point template and present it in a 2 min pitch at the CASA Chromametrics / Microseparations day on 30 March (showing style and colours she or he has chosen for our template for poster and presentations).
A commission from the CASAheads will choose between the top 3 (4) and decide who will be the winner of this contest.
Collaborative research article on IMER development for rapid digestion of proteins from dried blood spots published in the Journal of Chromatography A
Bert Wouters & Irena Dapic from the Department of Analytical Chemistry @ HIMS, UvA have reported on the utility and manufacturing of a cyclic-olefin-copolymer immobilised-enzyme reactor (IMER), using vinylazlactone chemistry to immobilise trypsin on a polymer monolith.
They performed several tests on a number of proteins and found high repeatability in terms of protein-sequence coverage and number of peptides. The IMER also showed very short protein digestion times, in the order of minutes to seconds (normally this procedure takes hours!). The application of dried blood spots containing a complex mixture of proteins was evaluated by Thalassa Valkenburg (on a secondment from the University of Leicester). The results showed that the workflow time for dried blood spot analyses could be reduced from 22.5 hours to 4 hours, thereby even omitting a treatment step (as can be seen in the figure for a traditional workflow (a) and IMER-facilitated workflow (b)).Full details can be read in the article
Politie onderzoekt gevaarlijk namaakvuurwerk
Volgens de politie zijn zo’n twintig verschillende soorten van de Cobra in omloop in Nederland, deels echt en deels namaak. Het Nederlands Forensisch Instituut (NFI) doet onderzoek naar de precieze samenstelling van het illegale knalvuurwerk."We kijken in eerste instantie naar de lading", vertelt onderzoeker Karlijn Bezemer van het NFI. "Wat zit er voor kruit in? Maar we zoeken ook naar kleurverschillen op de kokers en de plastic doppen."Het NFI doet ook een 'elementenanalyse' van het plastic in het vuurwerk. "We kijken echt diep in dat plastic om te checken wat er allemaal in zit", zegt Bezemer. "Aan de hand daarvan proberen we te herleiden wat de herkomst van het vuurwerk is."Volgens de politie is dat belangrijke informatie. "Als we weten welke fabriek welke Cobra maakt, kunnen we dat aan de voorkant gaan stoppen", zegt Nieuwdorp. Het onderzoek van het NFI duurt naar verwachting nog enkele maanden.
PhD Student Fleur van Beek of the Van 't Hoff Institute for Molecular Sciences (HIMS) was awarded the COAST prize for best analytical chemistry poster during the annual Dutch chemistry conference CHAINS 2016 in Veldhoven. She designed an "interactive" poster explaining the MAnIAC project of the HIMS Analytical Chemistry group.read more
Alina Astefanei, Irena Dapic and Michelle Camenzuli (Centre for Analytical Science in Amsterdam (CASA), Van’t Hoff Institute for Molecular Sciences, University of Amsterdam) published a review "Different Stationary Phase Selectivities and Morphologies for Intact Protein Separations" in Chromatographia as part of their special issue for “emerging young scientists” (topical collection Young Investigators in Separation Science).read the paper
The 2016 “Solvay Prize” is awarded to Dr. Bert Wouters (promotor Prof. Dr. S. Eeltink) for his work on groundbreaking research on the development of a microfluidic chip for spatial three-dimensional liquid chromatography. The prize will be presented on October 23rd 2016 at the ceremony in Brussels during the “Public Lectures” day organized by the International Solvay Institutes.
Dr. Bert Wouters performed his PhD research in the BioAnalytical Separation Science group within the Department of Chemical Engineering at the VUB in collaboration with the Schoenmakers group of the University of Amsterdam.
The aim of his research was to realize a novel multi-dimensional liquid-chromatography (LC) concept, i.e., comprehensive spatial three-dimensional (3D-)LC, which has unrivalled possibilities for high-efficiency LC separations. Therefore, a microfluidic chip was developed in which analytes migrate to different positions in a three-dimensional body.
Henrik Cornelisson van de Ven (UvA - Faculty of Science-Van 't Hoff Institute for Molecular Sciences) has been selected as one of the ten finalists for the Amsterdam Science & Innovation Award 2016. On 26 May, the winner of the Amsterdam Science & Innovation Award will be announced during the festive award ceremony.
Reflectron Modulation Interface (ReMI) - Making the incompatible compatible in analytical chemistry
ReMI makes incompatible approaches compatible for liquid analytical chemistry techniques. ReMI is a device that facilitates combinations of liquid chemical analysis instrumentation by transferring chemical fractions of interest from one medium to another. By being able to choose a liquid medium in such a fashion, combinatorial analysis approaches can now be envisioned that were not feasible before. This prospect of new combinations of analysis instruments opens up a world of possibilities for everyone who relies on chemical information in their research. Two processes can be consolidated into one, saving time and money, or instruments that provide complementary information could be coupled to provide completely new scientific insights.
ReMI’s patented principle works on the temperature effect on retention in Liquid Chromatography and is currently in advanced prototype form at the Analytical Chemistry group at the University of Amsterdam.
The scientists responsible for its invention are searching for partners that are interested in developing applications and bringing ReMI as a standalone device or an instrument add-on to the market.
The European Research Council (ERC) has awarded a prestigious Advanced Grant to Peter Schoenmakers, professor of Analytical Chemistry & Forensic Science at the University of Amsterdam (UvA). Schoenmakers receives this grant for his research project ‘Separation Technology for A Million Peaks’ (STAMP). The grant will allow Schoenmakers to develop new high-performance separation technology capable of separating up to a million chemical compounds overnight.
Extremely high separation powers are required to fully characterize complex mixtures that are of crucial importance in many fields, such as life science (including systems biology), food science, renewable energy sources and feedstocks, and high-tech materials. The STAMP project is aimed at obtaining a peak capacity of one million in liquid-phase analytical separations. Spatial three-dimensional liquid chromatography will be used to achieve this goal. The major advantage of this technique is that all second-dimension separations and – in a next step – all third-dimension separations are performed in parallel. This allows high-resolution separations to be performed in each dimension, while the total analysis time remains reasonable. Optical and mass-spectrometric imaging techniques are envisaged as detection methods after printing (STAMPing) the effluent from the 3D separation body on a suitable substrate.
The STAMP project also has a number of sub-targets that will bring additional significant benefits to all the above application fields.
The target and the sub-targets of the STAMP project may be summarized as follows.
- Separations with a peak capacity of 1,000,000 (through the use of spatial 3D-LC)
- Fast and efficient spatial 2D-LC separations
- Devices for spatial 2D-LC and 3D-LC
- Detection principles for spatial 2D-LC and 3D-LC
- Suitable stationary-phase materials and mechanisms for orthogonal 2D and 3D separations
- Relevant applications of all of the above in various fields of science
Bob Pirok, a PhD student within the MANIAC project at the UvA, has recently published his first paper in Journal of Chromatography A . Together with BSc student Jitske Knip, Bob has studied very complex mixtures of early synthetic dyes, their impurities and degradation products with comprehensive two-dimensional liquid chromatography (LC×LC). The interest in such samples originates from conservation science (Prof. Maarten van Bommel). B.W.J. Pirok, J. Knip, M.R. van Bommel, P.J. Schoenmakers, Characterization of synthetic dyes by comprehensive two-dimensional liquid chromatography combining ion-exchange chromatography and fast ion-pair reversed-phase chromatography., J. Chromatogr. A. 1436 (2016) 141–6. doi:10.1016/j.chroma.2016.01.070.
We have recently published a novel coupling approach for the online comprehensive coupling of Hydrophilic Interaction Liquid Chromatography × Reversed Phase LC and applied to the separation of surfactants (tristyrylphenol ethoxylate phosphate) used by one of our project partner (Syngenta). Using active modulation we could significantly reduce the dilution (enhance sensitivity), mobile phase usage and analysis time.read more
If you are interested in reading more follow this link (the article is in open access).
The University of Amsterdam (UvA), the Netherlands Forensic Institute (NFI) and the Dutch research organisation TNO are joining forces in forensic scientific research into explosives. In a new project named FEXIN, the parties will jointly develop forensic chemical methods to improve the investigation after an explosion or after explosives are found. The Amsterdam-based part of the project will be headed by professors Arian van Asten and Peter Schoenmakers of the UvA's Van 't Hoff Institute for Molecular Sciences (HIMS).read more
Analytical Sciences: Measurements Matterread the full review
The December CASA Day focused on the future of analytical sciences, with an emphasis on proteomics.
As the first year of CASA drew to a close, CASA members came together to discuss the future of analytical sciences in Amsterdam. Spui 25 was filled with members from CASA and beyond including guests from abroad who joined us to celebrate the inaugural lecture of Prof. Garry Corthals (UvA).
The proteome: it’s life, but not as we know it.
The key role of proteomics
The field of proteomics allows us to study cellular processes at the protein level. In his inaugural lecture, Garry Corthals reviews the rise of proteomics over the last 20 years and how it has ushered in new concepts in biology.
Ron Peters, professor of Bioterials Analysis
Dr R. Peters (1970) has been appointed professor by special appointment of Bioterials Analysis at the Faculty of Science (FNWI) of the University of Amsterdam (UvA). The chair was established on behalf of the Science Plus Foundation (Stichting Bèta Plus).
The 2015 edition of the "Analytical Sciences Power List" compiled by the magazine "The Analytical Scientist" again ranks Peter Schoenmakers at the seventh place. In a European perspective he holds the third position, as in the previous edition of 2013.
HPLC2015 Beijing was a fairly big conference, attended by some 625 scientists from about 30 different countries. Young Scientist Awards were presented to four Chinese Scientists and to Bob Pirok from the UvA for exceptionally good presentations.
Bob Pirok presented a lecture about PIOTR, an attractive MatLab-based software Program for the Interpretive Optimization of Two-dimensional Resolution in liquid chromatography, which he created from scratch in a very short time this summer. Using the current version of PIOTR, the typical time needed for developing an LCxLC method can be brought down from 2 to 4 months to two weeks or less.
Andrea Gargano has been awarded a VENI grant by NWO for his proposal on Intact-Protein Analysis. The grant amounts to k€ 250 and it allows Andrea to start his own independent line of research.
He aims to perform his research at University of Amsterdam (HIMS) in collaboration with The Netherlands Proteomic Centre (Professor Albert Heck, University of Utrecht) and the Proteomics Center of Excellence at Northwestern University (Evanston, IL, USA; Professor Neil Kelleher).
Andrea is currently a post-doctoral fellow in the TA-COAST HYPERformance LC project at the University of Amsterdam.
Highlight article on CASA published by Faculty of Science, UvA.
An innovative research project in the analytical sciences has received substantial funding by the Netherlands Organisation for Scientific Research NWO. The MAnIAC (Making Analytically Incompatible Approaches Compatible) project, led by Prof. Peter Schoenmakers of the Van 't Hoff Institute for Molecular Sciences, aims at combining analytical methods that until now have been considered incompatible. The total project budget is over a million euro.
Analytical devices are of great importance for modern society in areas such as health, food and the environment. In industrial and commercial applications they enable, for instance, important quality and safety assessments. In research and innovation they provide crucial information leading to thorough understanding.A beautiful example is the addition of mass spectrometry to gas chromatography. This yields the powerful GC-MS duo which is widely used in areas such as food analysis, drug development and environmental analysis. Various other combinations of analytical techniques are equally desirable, but much less attainable.
In many cases the combination of two analytical techniques is far more valuable than either one of the techniques individually.
Linking analytical devices
With their project “Making Analytically Incompatible Approaches Compatible” (ManIAC) researchers in analytical technology expect to significantly improve this. They aim at linking a large variety of analytical devices. This will allow much better and more efficient research in a broad range of current topics such as the development of sustainable raw materials and processes for the chemical industry.
The MAnIAC project is part of the Technology Area “Comprehensive Analytical Science and Technology” (COAST), a public-private partnership of the Netherlands Organisation for Scientific Research NWO with industrial partners. Prof. Peter Schoenmakers (UvA-HIMS) is the principal investigator and Dr Ron Peters (DSM, visiting scientist at the UvA) acts as MAnIAC project manager.
Other academic institutions involved are Radboud University (Prof. Dr Arno Kentgens), VU University Amsterdam (Prof. Dr Govert Somsen) and the University of Groningen (Prof. Dr Elisabeth Verpoorte). Private partners are Heineken, Shell, DSM and Micronit Microfluidics. The total project budget is 1,065,000 euro.
The research will be directed at the application areas of the participating companies. New combined instruments will become available to gain new insights in processes such as the degradation of various types of particles (natural materials, including milled grains, but also synthetic resins) and complex molecules, such as lignins. Moreover, microbial reactors will be studied in relation to the beer-brewing process.
Valorization beyond the MAnIAC project will be led by Micronit Microfluidics. This company will design and produce components that can be used for a near infinite array of applications. Creating a generic MAnIAC toolbox is a key objective of the project.
Prof. G.L. Corthals (1962) has been appointed professor of Supramolecular Separations at the Van ‘t Hoff Institute for Molecular Sciences (HIMS).
The Knox medal was awarded by the Analytical Division Separation Science Group of the Royal Society of Chemistry to Professor Peter Schoenmakers, Van't Hoff Institute for Molecular Sciences, University of Amsterdam. He received this medal at 13th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) in Bruges, January 2014.
HIMS professor holds top-ten position in 'Analytical Sciences Power List'. The 'Analytical Sciences Power List 2013' published by The Analytical Scientist magazine places UvA professor Peter Schoenmakers at an honourable seventh place. In a European perspective he even takes the third position. The power list is a ranking of the 100 'most influential people in the analytical sciences'. It is based on a poll among the readers of the magazine and the visitors of its website. They were invited to submit three names of scientists, engineers, software developers or business leaders in the field of the analytical sciences. The list not only measures influence, but also indicates 'who are shaping the most used and innovative techniques today'. Prof.dr.ir. Peter J. Schoenmakers is professor in Analytical chemistry including its application in forensic science at the Van 't Hoff Institute for Molecular Sciences (HIMS). He is leader of the Analytical Chemistry Group. Schoenmakers also holds several other positions such as Educational Director at COAST, the national Dutch organisation in the field of the analytical sciences. He is member of the editorial board at the Journal of Chromatography A.